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Slightly Bullish +25

Tracking Stanley Druckenmiller's Duquesne Family Office Portfolio - Q4 2025 Update

πŸ“Š Duquesne Family Office's portfolio value increased to approximately $4.49 billion in Q4 2025.

πŸ›οΈ The firm disclosed 35 significant holdings based on Stanley Druckenmiller's 13F filing dated February 17, 2026.

πŸ†• New positions were initiated in Alcoa, Entegris, Lattice Semi, Bloom Energy, and Delta Airlines at prices below current market levels.

πŸ“ˆ Conviction bets saw substantial increases, including Amazon (up ~92%), Coupang (~45%), Alphabet, Sea Ltd, and Newamsterdam Pharma.

⬇️ Notable large reductions were made in Natera, Insmed, Teva, Woodward, and Taiwan Semi holdings.

βœ‚οΈ The firm fully exited positions in Meta, Citigroup, and EQT from its 13F portfolio.

πŸ” The top five holdings remain led by Natera, Insmed, Amazon.com, Teva Pharma, and Woodward despite recent reductions.

⚠️ The article is part of a series analyzing quarterly changes to the Duquesne Family Office's stock portfolio for DIY investors.

Bullish Signals
  • The Duquesne Family Office portfolio value grew to approximately $4.49 billion in Q4 2025, led by 35 significant positions.
  • Major new stakes were initiated in companies like Alcoa, Entegris, Lattice Semi, Bloom Energy, and Delta Airlines at prices below current market levels, suggesting attractive entry points.
  • Significant stake increases were made in Amazon (up ~92%), Coupang (~45%), Alphabet, Sea Ltd, Newamsterdam Pharma, and BBB Foods, reflecting strong conviction in these names.
  • Amazon represents a top position with massive upside potential given the ~92% increase in ownership during the quarter.
Risk Factors
  • Large reductions were made in holdings of Natera, Insmed, Teva, Woodward, and Taiwan Semi, potentially signaling a loss of conviction or concern about their near-term prospects.
  • Major positions including Meta and Citigroup were fully exited from the portfolio, indicating a significant de-risking of exposure to these major technology and financial institutions.
  • The initiation of new stakes in Alcoa, Entegris, Lattice Semi, Bloom Energy, and Delta Airlines at prices below current market levels carries execution risk, as market conditions may deteriorate before the investor can exit or add positions.
Full Analysis
Duquesne Family Office, managed by Stanley Druckenmiller, increased its reported portfolio value to approximately $4.49 billion in the fourth quarter of 2025, with new filings released on February 17, 2026. The updated 13F filing highlights significant stake increases in major holdings such as Amazon, which saw a nearly 92% increase in position size, alongside notable additions to Alphabet, Sea Ltd, Coupang, and BBB Foods. The portfolio also featured several new initiations at prices below market levels, including positions in Alcoa, Entegris, Lattice Semi, Bloom Energy, and Delta Airlines, indicating strategic shifts into these sectors. In contrast to the growth seen in some areas, large reductions were executed in previous heavy holdings such as Natera, Insmed, Teva Pharma, Woodward, and Taiwan Semi (TSM). Additionally, the family office fully exited positions in Meta, Citigroup, and EQT, signaling a complete divestment from those specific equities. While Ticker/Topic C is not listed in the detailed breakdown of top or new positions within the core portfolio update provided in this text, it appears in the header listing along with other tickers like NU, GOOGL, and SE. The article focuses heavily on the quantitative changes to the broader Duquesne portfolio rather than detailing a specific narrative solely about ticker C, making C an incidental mention in this context of a family office-wide strategy update focused on biotech, tech, and energy sectors.